linkedin post 2016-12-20 06:00:03

NO CITRATE USERS. “In a long-term experiment, we propagated 12 populations of E. coli, all founded from the same ancestral strain, in a medium containing glucose, which is the limiting resource, and abundant citrate. For more than 30,000 generations, none of them evolved the capacity to use the citrate, although billions of mutations occurred in each population, such that any typical base pair mutation would have been tested many times in each one.”

http://www.pnas.org/content/105/23/7899.full

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