NETWORK BUFFERING. “The same benefits of modularity that were evoked to hypothesize why cis-regulatory changes would be less pleiotropic than functional changes apply as well to the modularity of GRNs as effectors of gene regulation and expression, with the GRN acting as a buffer against any widespread negative effects of a coding mutation in a developmental gene.” (GRN = gene regulatory networks).
https://lnkd.in/dD4GcAS
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022