WATSON AND CRICK’S DOUBLE HELIX just expanded to four. “G-quadruplexes, so-called because they form in guanine-rich DNA sequences, are not just a structural curiosity – they form at sites across the genome in living cells. Cancers are usually driven by genes called oncogenes that have mutated to increase DNA replication – causing cell proliferation to spiral out of control, and leading to tumour growth. The increased DNA replication rate during oncogenesis leads to an intensity in the quadruplex structures.”
https://lnkd.in/dn_e5kr
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022