JACOB OVERTHROWN. “Gene duplication, fusion and fission of genes, exon shuffling and other ‘bricolage’ events were considered to be the only viable sources of novel protein-coding genes—all variations on a genetic theme. Proteins were thought to be made from a small and finite ‘universe of exons’. Francois Jacob articulated this best when he said ‘To create is to recombine’. However, in recent years, there has been a growing appreciation for the role of de novo gene origination.”
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