INTEGRATION OF NEW GENES. “Our results unveil a remarkable network topological integration process of new genes: over 5000 new genes were integrated into the ancestral GGI networks of human and mouse; new genes gradually acquire increasing number of gene partners; some human-specific genes evolved into hub structure with critical phenotypic effects.” (GGI = Gene-gene interaction networks).
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0772-4