RARE EVENTS. “Keefe and Szostak derived ATP-binding proteins from 80 amino acid random sequences using high-diversity mRNA display (6 × 10(12) variants)…In their selection, an estimated frequency of 1 in 10(11) random sequence proteins was able to bind ATP. Interestingly, the selected proteins showed no significant homology with biological ATP-binding motifs suggesting that there are novel folds not sampled by nature for this specific purpose.”
https://lnkd.in/e3rTkFh
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022