HERETICS FIRST. “Not surprisingly, Woese’s work was originally doubted, even ridiculed, by many biologists. One referred to him as “a crank, who was using a crazy technique to answer an impossible question”. Subsequent improvements in sequencing technology, however, allowed the confirmation of a three-domain biosphere, of which the two prokaryotic realms are essentially alien to classical biology. Now, the three-domain view is well established, even at the level of introductory textbooks.”
https://standardsingenomics.biomedcentral.com/articles/10.1186/s40793-016-0180-8