MALFUNCTIONS AND DISEASE. “Among multi-cellular eukaryotes, when genetic or genomic changes produce significant adverse effect, many of the resulting problems are produced by perturbations in development, or disruptions of a complicated bit of physiology necessary to accomplish some critical function in differentiated somatic tissue.”
https://standardsingenomics.biomedcentral.com/articles/10.1186/s40793-016-0180-8