PERTURBATION BIOLOGY. “A common definition of systems biology is the study of a given biological system by (a) the perturbation of a property of that system, (b) the measurement of resulting gene, protein, and pathway responses, (c) the integration of these data, and (d) the ultimate modeling of these data to describe the system as well as its response to perturbation.” Exceptional paper.
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1