OCCLUDED MOLECULAR SYSTEMS. “There are still methodological and conceptual limitations that must be overcome to bridge the gap between simple gene expression analysis and the inference of molecular systems. For example, most of the popular differential gene expression methods that are used for variable selection provide single gene-based assessments of differential expression.”
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1