NEW TOOLS. “There are now a multitude of implementations based on this concept that introduce additional functional data such as protein interaction data, gene regulatory networks, pathway topology information, metabolic changes or expression kinetics. These methods have been applied not only to understand gene expression changes but also in Genome-Wide Association Studies (GWAS), comparative genomics and gene prioritization.”
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1