EPIGENETIC REPROGRAMMING. “It is proposed that the absence of a functionally important methyl group in a promotor or operater region produces a recombinator or signal for the initiation of recombination. The formation of hybrid DNA in this region then allows the lost methyl groups to be replaced by maintenance methylase activity. The removal of epigenetic defects by recombination during meiosis therefore becomes an essential part of a reprogramming and rejuvenation process.”
http://europepmc.org/abstract/med/6400219
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022