INCREASING MOLECULAR DISORDER. “It is because of these considerations that I propose that telomere shortening may be the molecular equivalent of longevity determination, not aging, and that the increasing molecular disorder that is known to occur in normal cells as telomeres shorten is equivalent to age changes. As indicated earlier hundreds of biological changes occur in normal cells as the age in vitro representing increasing molecular disorder and all compromise the internal milieu that ultimately leads to the Phase III Phenomenon.”
http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html