DEPENDENT GENES. “The genome as ‘an organ of the cell’. And so it is. DNA sequences do absolutely nothing until they are triggered to do so by a variety of transcription factors, which turn genes on and off by binding to their regulatory sites, and various other forms of epigenetic control, including methylation of certain cytosines and interactions with the tails of the histones that form the protein backbone of the chromosomes. All of these, and the cellular, tissue and organ processes that determine when they are produced and used, ‘control’ the genome.”
http://rsfs.royalsocietypublishing.org/content/2/1/55