QUESTIONS. “The first multicellular animals and plants belonging to the eukaryote terminal crown group are believed to have appeared around 0.7 to more than one billion years ago. Were they the first living beings whose cells were endowed with the capacity to self-destruct? Were effectors of cell suicide already present and operational in the first multicellular animals and plants, or were they selected later from other ancestral signaling pathways? When did the capacity to self-destruct initially appear?”
http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html