DRIVEN TO EXTINCTION. “At a snapshot in time, hazards lie low for a stretch of ages, climb at ages where remaining net fertility is dropping off, and link up with the old-age segment. As time goes by, the climbing phase shifts down to younger and younger ages, until the hazard rate at every adult age comes to be marching toward infinity. Unbounded accumulation of mutations across the whole reproductive span drives any population to extinction.”
http://www.pnas.org/content/110/25/10141.full