RESISTANCE PHENOTYPES. “In the studies with HCV it was important to exclude that inhibitor resistance mutations had not been acquired as a consequence of fitness gain. This possibility was excluded not only by NGS but also by the multiplicity of infection (MOI)-independent kinetics of virus production in the presence of inhibitors, and the maintenance of the resistance phenotype in biological clones of the passaged populations.”
http://www.sciencedirect.com/science/article/pii/S0042682215001580
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022