COMPLEX DOCKING OBJECTIVE. “We sought to understand how the adaptive landscape led to an innovation whereby bacteriophage l evolved the new ability to exploit a receptor, OmpF, on Escherichia coli cells. Previous work showed that this ability evolved repeatedly, despite requiring four mutations in one virus gene.”
http://rspb.royalsocietypublishing.org/content/royprsb/283/1839/20161528.full.pdf