HIGHLY ADAPTABLE. “Upon changes in the replication environment, minor variants that fit best to replicate in the new environment receive selective advantages. Consistent with this view, a growing number of studies have highlighted the fact that prion strains exhibit high levels of conformational plasticity and are subject to transformation when exposed to new replication environments.”
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003759