SO ENDS this first of two weekends contemplating the genetic origin of protein diversity in organisms and its consequences. This mechanism is at the heart of generating protein diversity from a relatively small deck of genetic cards, and thus, is at the heart of the capacity to evolve and develop new functionality from different structures. By constantly varying the structures of core motifs, new protein functions can be found by trial and error. Whether there is any statistical bias will reveal whether life can be capable of directing its own evolution in a goal-oriented manner.