CLOCK PATHWAY DEFICIENCIES. “Mice deficient in Bmal1 alter glucose and insulin secretion. Bmal1−/− mice increase concentrations of circulating fatty acids resulting in formation of ectopic fat in the liver and skeletal muscle. When rhythmicity is rescued in Bmal1−/− mice with Bmal2, insulin secretion and activity patterns are restored.”
https://lnkd.in/dH6Ha79