KEY CONCEPT. “Britten and Davidson furthered this idea by introducing the concept of gene regulatory networks (GRNs) as hierarchical operating systems regulating mammalian development. Their early conceptualization of a metazoan GRN was visionary, anticipating many elements of current network theory and evolution, including redundancy, feedback regulation, the relationship between genome size and regulatory complexity, and the role of nuclear RNA in network regulation.” (GRN = gene regulatory networks).
https://lnkd.in/dfCi2dc