ALCHEMICAL ROOTS. “The ability of plants to act upon the human constitution gave rise to a language of “active principles” which persisted through the centuries, even as its meaning changed. Within the alchemical tradition, the notion that matter itself could have an active component was continuously intertwined with efforts to capture the intoxicating powers of fermented plants.”
https://www.tandfonline.com/doi/full/10.1080/00026980.2020.1867786