TOXICOLOGY. “Small levels of deuteration are, nevertheless, harmless. This is understandable given the fact that about 1 in every 6400 hydrogens in nature is found in its stable isotope form of deuterium. Oral doses of several milliliters of D2O are safe for humans and are used in the isotopic form D218O for metabolic measurements in clinical praxis (known as “doubly labeled water” technique).”
https://www.nature.com/articles/s42003-021-01964-y