linkedin post 2021-05-01 05:56:26

SWEETENERS. “Interestingly, not all artificial sweeteners are recognized by rodents. Differences in human and rodent responses to tastants, as well as sweetness inhibitors such as lactisole, have been useful for delineating the molecular recognition of sweet compounds—using human-mouse chimeric receptors, it was shown that the transmembrane domain (TMD) of human TAS1R3 is required for the activating effects of cyclamate29 and for the inhibitory effect of lactisole.”

https://www.nature.com/articles/s42003-021-01964-y

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