IMPACT OF COMPETITION FOR RESOURCES. “This would lead to the canalization of development and would explain the stability and irreversibility of differentiation. This is what Spiegelman had also noted. Waddington noted that others such as Darlington, Lindegren, Spiegelman, and Sonneborn, have proposed such self-duplicating plasmagenes on genetic evidence, but that this type of entity fit in well with the observed facts of embryology.”
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