KNOCK-OUTS. “Later, parallel mutations in the adenine DNA glycosylase gene (mutY) arose in independent lineages; these mutations approximately halved the mutation rate, apparently by knocking out a mechanism by which misincorporations of oxidized nucleotides during DNA replication (caused by the original mutT defect) were misrepaired. The resulting reduction in genetic load was estimated to be ~0.5%.”
https://www.nature.com/articles/nrg3564
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022