EPIGENETIC FINGERPRINT. “On a genome-wide scale, 5,409 CpG sites were found to be differentially methylated in day-time versus night-time shift workers, and a remarkable 66% of these loci were hypermethylated. Similarly, CpG methylation of the PER1, PER2 and PER3 promoters was found to correlate with changes in protein expression in 50% of breast tumors versus normal tissue taken from the same patient.”
https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022