Month: September 2022

DISTRIBUTION. “Introns of lincRNA genes contain the highest percentage of TE-derived sequences (TES), followed by exons and then promoter regions although the density of TEs is not significantly different between exons and promoters.” (TE = transposable elements); (lincRNA = Long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

THE SPLIT. “Higher frequencies of ancient TEs in promoters and exons compared to introns implies that many lincRNA genes emerged before the split of primates and rodents.” (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

SKEW. “The content of TES in lincRNA genes is substantially higher than that in protein-coding genes, especially in exons and promoter regions.” (lincRNA = Long intergenic non-coding RNA); (TE = transposable elements); (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

PREFERENTIAL. “A significant positive correlation was detected between the content of TEs and evolutionary rate of lincRNAs indicating that inserted TEs are preferentially fixed in fast-evolving lincRNA genes.” (lincRNA = Long intergenic non-coding RNA); (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

FAST DIVERSIFICATION. “These results are consistent with the repeat insertion domains of LncRNAs hypothesis under which TEs have substantially contributed to the origin, evolution, and, in particular, fast functional diversification, of lincRNA genes.” (lincRNA = Long intergenic non-coding RNA); (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

SURPRISE. “Strikingly, the total number of genes for ncRNAs that are expressed from a mammalian genome seems to exceed the number of protein-coding genes several fold.” (ncRNA = non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

UNCHARACTERIZED. “The current knowledge on the functions of long intergenic non-coding RNAs (lincRNAs) is scarce because very few of the lincRNAs have been experimentally characterized.” https://lnkd.in/dwuaM5f View in LinkedIn

POSSIBLE FUNCTIONS. “Nevertheless, the functional range of this class of ncRNA is believed to be broad on the basis of indirect evidence. It has been proposed that lincRNAs could be involved in the regulation of many cellular processes.” (lincRNA = long intergenic non-coding RNA; ncRNA = non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

NOT CONSERVED. “It is well established that, compared to protein-coding sequences and structural RNAs, lincRNAs are weakly conserved in evolution.” (lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

CHANGING VIEW. “Many early studies, therefore, branded the lincRNAs “transcriptional dark matter” and considered them to be generally non-functional. However, low level or lack of detectable conservation does not necessarily imply that these molecules have no function.” (lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn