linkedin post 2017-08-13 06:13:55

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SAFETY BUFFER. “Vitamin C is concentrated by most tissues in humans and in many mammals. However, only much lower concentrations, sometimes 1–2 orders of magnitude lower, are required for the known enzymatic actions of vitamin C. Why do tissues so avidly acquire vitamin C? A possible explanation is that maintaining concentrations in great excess above the required function may be an evolutionary protective or ‘safety’ function.” https://lnkd.in/dhzW8hm View in LinkedIn
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linkedin post 2017-08-13 06:19:44

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POSSIBLE CANCER EFFECTS. “Few experimental cancer therapies have incited as much debate as vitamin C. More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations and are often refractory to approved targeted therapies. We found that cultured human CRC cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C.” http://science.sciencemag.org/content/350/6266/1391 View in LinkedIn
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linkedin post 2017-08-13 06:22:28

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CONFOUNDING TRIALS. “The results of vitamin supplementation trials have been disappointing at best, despite having a solid mechanistic basis. One explanation for this result could be that the physiologic systems affected by vitamins and other antioxidant supplements are so complex that the effects of supplementing with only 1 or 2 components is generally ineffective or actually does harm.” https://lnkd.in/dS_KnV5 View in LinkedIn
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linkedin post 2017-08-13 06:23:55

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SIGNIFICANT EFFECTS. “Two good-quality trials of multivitamin supplementation found lower cancer incidence in men. The SU.VI.MAX trial included women and did not find an effect in this subgroup. We found a statistically significant protective effect from multivitamin supplementation when we pooled data for men in these 2 trials.” https://lnkd.in/dS_KnV5 View in LinkedIn
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linkedin post 2017-08-13 06:25:10

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SO ENDS this contemplation of the vitamin C gene, its losses and reactivations, and the development of a novel synthetic pathway in photosynthetic eukaryotes by massive lateral gene transfer. Two-time unshared Nobel Laureate Linus Pauling was a strong advocate of vitamin augmentation, but his work was largely ignored. Today, the debate still rages on. http://articles.mercola.com/sites/articles/archive/2015/11/23/vitamin-c-curative-power.aspx View in LinkedIn
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linkedin post 2017-08-14 06:05:20

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NUCLEAR BODIES. "Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing." https://lnkd.in/duRrssZ View in LinkedIn
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linkedin post 2017-08-14 06:10:14

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NEW ORGANELLE. "Paraspeckles are one of the most recent subnuclear bodies identified, discovered in 2002 as part of a study to better understand the full biological role of the nucleolus. In a mass spectrometry based proteomic analysis of purified human nucleoli, 271 proteins were identified, ∼30% of which were novel." https://lnkd.in/duRrssZ View in LinkedIn
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