Month: September 2022

ARBITRARY FUNCTIONAL ASSIGNMENTS. “The assignment of genes to functions is still a largely unfinished task and the boundaries of pathway definitions are arbitrary: one database might include a set of genes within a specific signaling pathway while another would split this into two separate pathways.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

TRANSCRIPTS ARE KEY. “As gene expression analysis continues the transition to high-throughput sequencing, transcripts rather than genes become the fundamental feature measured and will require the update of functional profiling methods to support transcript-level functional analyses of enrichment.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

MORE SOLOS. “Although genomics and systems biology have started to reshape a multitude of areas in biology, new subfields evolve with ever more specialization. Ironically, we suspect that systems biology and genomics are in fact contributing to a new era of specialization by creating entire new subfields such as developmental systems biology or pharmacogenomics.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

DATA ALONE IS INSUFFICIENT. “As genomics continues to expand and to mature by addressing nearly every imaginable biological question, it is increasingly clear that the primary analysis of the resulting data alone is no longer sufficient for extracting new biological insights.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

BEYOND DATA ALONE. “Instead, we need to leverage the ideas and techniques of systems biology to understand the behavior of the system and its multitude of parts. Similarly, the challenges that genomics is now tackling by integratively analyzing ever higher-dimensional, multi-species systems will likely require the development of more sophisticated hierarchical models by the systems biology community to enable meaningful joint comparative analyses.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

PATIENT DAYA CLOUD. “Last but not least, genomics will need to leverage systems biology by building predictive models from personal genome data to produce actionable results for patient care that delivers on the promise of precision medicine.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

SO ENDS this remarkable paper that talks about the transition from bench to bedside in the genomics world, and how it applies especially to personalized medicine. Look at Arivale Inc by Leroy Hood or Craig Venter’s Longevity Inc as commercial efforts in this exciting sector. https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

LIFE EXTENSION is the subject of the next string of postings. Frankly, I began this adventure as a vigorous skeptic, tiered of the usual cosmetic industry claims. However, I have been more than a little surprised at what I found. Join the ride and see if you too become a new optimist about the possibilities and opportunities to enter a Brave New World. View in LinkedIn

IMMORTALITY FROM A BIOLOGICAL PERSPECTIVE is the only serious way to explore this topic. My tenure does not rely on being mainstream and avoiding hot topics, so I have the valuable freedom to venture into third rail subjects at will. View in LinkedIn

"WORLD, world, O world!" "But that thy strange mutations make us hate thee," "Life would not yield to age." " "(Edgar, Act 4, Scene 1), King Lear, by William Shakespeare. https://lnkd.in/eVsTRgw View in LinkedIn