Month: September 2022

NEGLIGIBLE AGING. ""According to the Animal Ageing and Longevity Database, the list of organisms with negligible aging (along with estimated longevity in the wild) includes: Rougheye rockfish (Sebastes aleutianus) – 205 years; Olm (Proteus anguinus) – 102 years; Painted turtle (Chrysemys picta) – 61 years; Blanding's turtle (Emydoidea blandingii) – 77 years; Eastern box turtle (Terrapene carolina) – 138 years; Red sea urchin (Strongylocentrotus franciscanus) – 200 years; Ocean quahog clam (Arctica islandica) – 507 years; Great Basin bristlecone pine (Pinus longaeva) – 4,713 years." https://lnkd.in/dYChGXk View in LinkedIn

AMPHIBIAN LIMB REGENERATION. "The ability to regenerate complex structures is widespread in metazoan phylogeny, but among vertebrates the urodele amphibians are exceptional. Adult urodeles can regenerate their limbs by local formation of a mesenchymal growth zone or blastema." https://lnkd.in/dxZ4YAq View in LinkedIn

SALAMANDERS AND FROGS. "While the limb skeletal pattern is well conserved among tetrapods, limb regenerative capacity differs from animal to animal. Salamanders can regenerate their limbs completely, but amnoites (lizards, birds and mammals) cannot regenerate their limbs. Frogs exhibit different degrees of limb regenerative capacity at different stages of their life cycles." https://lnkd.in/d5zM_n7 View in LinkedIn

"ANURAN AMPHIBIANS such as Xenopus are intermediate between urodele amphibians and other vertebrates in terms of their regenerative capacity, in that they can completely regenerate developing hindlimb buds prior to the onset of metamorphosis, but regenerative capacity declines gradually as metamorphosis proceeds." http://onlinelibrary.wiley.com/doi/10.1111/j.1440-169X.2007.00973.x/full View in LinkedIn

PRECISE REPLICA. "Regeneration is an ability that has been observed extensively throughout metazoan phylogeny. Amongst vertebrates, the urodele amphibians stand out for their exceptional capacity to regenerate body parts such as the limb. During this process, only the missing portion of the limb is precisely replaced—amputation in the upper arm results in regeneration of the entire limb, while amputation at the wrist produces a hand." https://lnkd.in/dYbZKyW View in LinkedIn

APPLICATIONS. "We review what is known about amphibian limb regeneration from the prospective of developing strategies for the induction of regeneration in adult mammals." https://lnkd.in/d_NDPcr View in LinkedIn

AXOLOTLS. "Urodele amphibians such as newts and salamanders can regenerate their limbs following amputation any time during their life cycles, although there is a non-regenerative mutant in axolotls." http://onlinelibrary.wiley.com/doi/10.1111/j.1440-169X.2007.00973.x/full View in LinkedIn

ANNELID REGENERATION. "Substantial somatic regeneration also occurs among other invertebrates, including members of relatively highly organized groups such as annelids." (Segmented worms and leeches). https://muse.jhu.edu/article/53800/summary View in LinkedIn

ADULT VS EMBRYO. "In adult mammals such as mice and humans, the wound heals and a scar is formed after injury, while wound healing is completed without scarring in an embryonic mouse. Completion of regeneration and wound healing takes a long time in regenerative and non-regenerative limbs, respectively.” http://onlinelibrary.wiley.com/doi/10.1111/j.1440-169X.2007.00973.x/full View in LinkedIn

"EMBRYONIC and neonatal mice can regenerate their digit tips if they are amputated through the distal phalanx, and similar digit tip regeneration occurs in humans." http://onlinelibrary.wiley.com/doi/10.1111/j.1440-169X.2007.00973.x/full View in LinkedIn