Month: September 2022

“APOPTOSIS is the programmed cell death mechanism that is most widespread in nature.” https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

THREE APOPTOTIC PURPOSES. "Apoptosis serves three main purposes in animals." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

APOPTOSIS #1. "The first one is the removal of cells which are no longer necessary, such as cells which played a role during development but are not needed in the adult, or immune cells after the pathogen has been cleared." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

APOPTOSIS #2. "The second purpose is the elimination of damaged cells, which may not be able to perform their function properly, or are potentially dangerous to the organism (for instance, cells with DNA damage which may lead to mutations)." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

APOPTOSIS #3. "The third main function is the elimination of infected cells." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

DEATH AS CARNAGE? "A significant fraction of the cells that are generated in C. elegans are subsequently eliminated by programmed cell death: about 12% during somatic development, even more in the germ line. Many a student of C. elegans, impressed by the efficiency and finesse of its development, has marveled at this apparent waste of energy." https://lnkd.in/dVeZ2yE View in LinkedIn

DEPTH AND DEFINITIONS. "How far “down” the evolutionary ladder one can expect programmed cell death to exist depends on how one defines the phenomenon." https://lnkd.in/dVeZ2yE View in LinkedIn

IMPLAUSIBLE IDEA. "It has been argued that for unicellular organisms, there would a priori appear to be no need for such a program, as cell death basically translates into organismal death and therefore would confer no evolutionary advantage (dead organisms do not procreate)." https://lnkd.in/dVeZ2yE View in LinkedIn

PLAUSIBLE IDEA. "However, if the unicellular organisms have the ability to recognize their kin, or simply tend to live in close proximity of each other, then this argument is no longer valid: One can easily envision that a unicellular organism could kill itself for the better good of its neighboring relatives, thus furthering the survival and multiplication of its own genes." https://lnkd.in/dVeZ2yE View in LinkedIn

APOPTOSIS and cell suicide are continuous ongoing processes in living systems. It is normal and widespread. "The cells of a multicellular organism are members of a highly organized community. The number of cells in this community is tightly regulated—not simply by controlling the rate of cell division, but also by controlling the rate of cell death. If cells are no longer needed, they commit suicide by activating an intracellular death program." https://lnkd.in/eaj7Brc View in LinkedIn