Month: September 2022

"DOMOIC ACID is two to three times more potent than kainic acid and 30 to 100 times more potent than glutamate" in animal models. https://lnkd.in/ezgTzXm View in LinkedIn

MECHANISM OF ACTION. Domoic acid "is structurally related to kainic acid, which is an analogue to the excitatory amino acid and neurotransmitter L-glutamate." https://lnkd.in/e3pZBba View in LinkedIn

MECHANISM OF ACTION. Domoic acid "activates the AMPA/KA-Receptor, which induces increased levels of intracellular Ca2+ which, in turn, causes glutamate release that subsequently activates the NMDA-Receptor." https://lnkd.in/e3pZBba View in LinkedIn

MECHANISM OF ACTION. "Activation of AMPA/KA-Rs (direct) and NMDA-Rs (indirect) can cause apoptotic and necrotic neuronal cell death." https://lnkd.in/e3pZBba View in LinkedIn

DOMOIC ACID. "Domoic acid is a kainic acid analog neurotoxin that causes amnesic shellfish poisoning. It is produced by algae and accumulates in shellfish, sardines, and anchovies" through the ingestion of certain algal blooms. "Exposure to the biotoxin affects the brain, causing seizures, and possibly death." https://lnkd.in/ea6_24c View in LinkedIn

GLUTAMATE RECEPTORS. "Glutamate (Glutamic acid) is the most prominent neurotransmitter in the body, and it is the main excitatory neurotransmitter, being present in over 50% of nervous tissue." https://lnkd.in/eMAKUzc View in LinkedIn

GLUTAMATE RECEPTORS. "One of the major functions of glutamate receptors appears to be the modulation of synaptic plasticity, a property of the brain thought to be vital for memory and learning." The main target of domoic acid. https://lnkd.in/eMAKUzc View in LinkedIn

AMNESIC SHELLFISH POISONING (ASP): main symptoms of domoic acid poisoning: acute: headache, seizures, hemiparesis, opthalmoplegia, and arousal abnormalities." https://lnkd.in/ezgTzXm View in LinkedIn

AMNESIC SHELLFISH POISONING (ASP): main symptoms after a few months: 12/14 severe patients had severe anterograde memory deficits and neuropathies. No surprise given the central role of glutamate receptors in domoic acid poisoning. https://lnkd.in/ezgTzXm View in LinkedIn

TOUGH TOXIN. "There is no known antidote available for domoic acid, so if symptoms fit the description, it is advised to go quickly to a hospital. Cooking or freezing affected fish or shellfish tissue does not lessen the toxicity." https://lnkd.in/eysn5Z5 View in LinkedIn