Month: September 2022

"ATP SYNTHASE is a huge molecular complex (>500,000 daltons) embedded in the inner membrane of mitochondria. Its function is to convert the energy of protons (H+) moving down their concentration gradient into the synthesis of ATP." https://lnkd.in/e5CY-iH View in LinkedIn

HUMMING ATP SYNTHASE MACHINE. "3 to 4 protons moving through this machine is enough to convert a molecule of ADP and Pi (inorganic phosphate) into a molecule of ATP. One ATP synthase complex can generate >100 molecules of ATP each second." https://lnkd.in/e5CY-iH View in LinkedIn

THE ONLY UNIVERSAL NANOMOTOR. "Biological motors are molecular machines found in living systems. Among all known biological nanomotors, ATP synthase stands alone for being the universal nanomotor found in all living systems from bacteria to man." https://lnkd.in/eTYm4q6 View in LinkedIn

CARTOON OF ATP SYNTHASE FUNCTIONALITY. This animation cleverly depicts what entire articles are hard pressed to express, namely, the finely-tuned and intricate function of the proton gradient in the enzyme, and how precisely the entire process operates while spinning at 9,000 RPM. https://lnkd.in/efhjzCY View in LinkedIn

TWO MOTORS AND A ROTOR. "ATP, the fuel of life, is produced in living cells by a complex molecular machine consisting of two motors linked by a rotor." https://lnkd.in/eahb8Gv View in LinkedIn

TWO MOTORS AND A ROTOR. "One motor generates rotation by consuming energy derived from oxidative metabolism or photosynthesis; the other uses energy transmitted by the rotor to put ATP molecules together from their building blocks, ADP and phosphate." https://lnkd.in/eahb8Gv View in LinkedIn

9,000 RPM MINI-MOTOR. "During ATP synthesis, the central rotor turns...about 150 times every second. In order to provide energy to sustain our lives, every day, each one of us produces a quantity of ATP by this mechanism that is approximately equal to our body weight." A number of commercial motors operate at 9,000 RPM. https://lnkd.in/eu4ehmH View in LinkedIn

TEXT OF ATP SYNTHASE FUNCTIONALITY. This is a thoroughly granular description of one ATP synthase, with details of the molecular pockets, architecture of the peripheral stalks and their subunits. This gives a detailed picture of the sheer complexity of this molecule. https://lnkd.in/eERctEF View in LinkedIn

THE CORE MACHINERY "is the subcomplex F1-motor (F1-ATPase) and performs the reversible mechanochemical coupling. The isolated F1-motor hydrolyzes ATP, which is accompanied by unidirectional rotation of its central gamma shaft." https://lnkd.in/eYcwEF7 View in LinkedIn

THE CORE MACHINERY. "When a strong opposing torque is imposed, the gamma shaft rotates in the opposite direction and drives the F1-motor to synthesize ATP." https://lnkd.in/eYcwEF7 View in LinkedIn