Month: September 2022

JUNK DRAWER. "Since ERVs are not random bits of DNA but complex sequences that code for various functional domains such as binding sites, proteases, promoters, and fusion domains, the likelihood of pulling something useful out of the ERV junk drawer is rather high, even if the item wasn't originally designed for the particular task." http://schaechter.asmblog.org/schaechter/2014/06/retroviruses-the-placenta-and-the-genomic-junk-drawer.html View in LinkedIn

LUCKY FLUKE. "It is amazing to think that an evolutionary innovation of such consequence — the placenta — was essentially pulled from the genomic junk drawer!" http://schaechter.asmblog.org/schaechter/2014/06/retroviruses-the-placenta-and-the-genomic-junk-drawer.html View in LinkedIn

RECOMBINANT INNOVATION. "Thomas Edison, Henry Ford, and now their modern counterparts were able to create one breakthrough after another because they built innovation strategies around recombining existing technologies rather than inventing new ones." https://lnkd.in/eGbBMDi View in LinkedIn

"INNOVATORS rarely come up with new ideas; instead, they convert old ideas into new ones, adapting them from one context to another. https://lnkd.in/ekkzkwr View in LinkedIn

THOUSANDS OF GENES. "A comprehensive expression profiling encompassing the full lifetime of the murine placenta from embryonic day 8.5, at the time of chorioallantoic fusion, until postnatal day 0 (P0), just after birth, uncovered a striking molecular transition occurring during mid-gestation. This transition separates two phases of placentation that are distinct on a molecular level and encompasses thousands of genes." https://lnkd.in/eN_bZTg View in LinkedIn

MID-GESTATIONAL TRANSITION. "The transition is not simply due to the expansion of an individual cell type, but appears to be a global shift in gene usage in the absence of major morphological change." https://lnkd.in/eN_bZTg View in LinkedIn

OTHER MEMBRANE FUSION ROLES. "Syncytin-1 and Syncytin-2...these ERV proteins, in addition to their localization at the cell surface of cytotrophoblasts, are also incorporated on the surface of various extracellular microvesicles, including exosomes." https://lnkd.in/eNxap6v View in LinkedIn

OTHER MEMBRANE FUSION ROLES. "Syncytin-1 and Syncytin-2...these ERV proteins, in addition to their localization at the cell surface of cytotrophoblasts, are also incorporated on the surface of various extracellular microvesicles, including exosomes." https://lnkd.in/eNxap6v View in LinkedIn

VIRAL DOMINANCE. "So powerful and ancient are viruses, that I would summarize their role in life as ‘Ex Virus Omnia’ (from virus everything)." https://lnkd.in/etdQ9rN View in LinkedIn

ALTERNATIVE VIEW. "A virus first perspective is presented as an alternative hypothesis to explain the role of various endogenized retroviruses in the origin of the mammalian placenta." https://lnkd.in/etdQ9rN View in LinkedIn