Month: September 2022

DIET AND DISEASE. "Based on these evidences, challenging questions may be raised regarding how humans pick up microRNAs from diet and what are the broader roles played by such exogenous microRNAs in human disease processes." https://lnkd.in/ej7XF-E View in LinkedIn

DIET AND HEALTH. "Many people carefully monitor their food choices, adhering to the philosophy that ‘you are what you eat’. Recent research adds a new wrinkle to that old adage, suggesting that dietary small RNAs (sRNAs) can control the gene expression of the consumer and may provide an effective, noninvasive, and inexpensive therapy for many human diseases." http://www.sciencedirect.com/science/article/pii/S0167779915001250 View in LinkedIn

miRNA AS MARKERS. "The differential expression and responses of selected c-miRNAs in overweight/obese individuals to an exercise and diet intervention suggests a putative role for these ‘biomarkers’ in the prediction or detection of individual variability to weight loss interventions." https://lnkd.in/eSJwPqc View in LinkedIn

miRNA AND NEURODEGENERATION. "Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau." https://lnkd.in/esYAtUn View in LinkedIn

ANOTHER exogenous dietary factor implicated in a variety of diseases are prions. Like mRNAs, they are also protected by exosomes, and like mRNAs, are controversial. Like mRNAs, prions are epigenetic regulators. Like mRNAs, prions can have both positive and negative effects on health. Like mRNAs, there are also endogenous sources of prions. View in LinkedIn

PRION DISEASES are caused by a mis-folded normal protein that is infectious, that acts as a template to induce other normal proteins to become mis-folded. Mad Cow disease is one example, that famously was contracted by eating infected meat of cows fed with infected cow meat. Clearly, these proteins were not destroyed in the human gut. Definitely Grey Zone entities. View in LinkedIn

MEMBRANE VESICLES. "Exosomes are small membrane-bound extracellular vesicles (80-160 nm) released from cells, and have been implicated in many diseases, including cancer, viral infection and neurodegenerative diseases" as well as miRNA transmitted effects in gene regulation. https://lnkd.in/ea-rNpb View in LinkedIn

ROLE OF EXOSOMES. "Exosomes play important roles in intercellular communication, including regulating immune responses following bacterial invasion, presentation of antigens for activation of T cells, and more recently, a novel mechanism of intercellular transfer of mRNA and miRNA, resulting in an additional level of regulation." https://lnkd.in/ea-rNpb View in LinkedIn

PRION TRANSMISSION. "The precise mechanism by which prions are transmitted from cell to cell remains yet to be fully elucidated, although three hypotheses have been proposed: direct cell-cell contact, tunnelling nanotubes and exosomes." https://lnkd.in/ea-rNpb View in LinkedIn

IDEAL PRION VEHICLE. "Given the reported presence of exosomes in biological fluids as well as the lipid and nucleic acid contents of exosomes, these vesicles represent an ideal mechanism for encapsulating prions and potential cofactors to facilitate prion transmission." http://www.jbc.org/content/early/2016/01/14/jbc.M115.684258.short View in LinkedIn