Year: 2022

EPIGENETICS is the other large chunk of the hidden iceberg in genomics. Genes are far from stationary fixed elements. Epigenetics is all about how genes get activated or silenced. The environment, drugs, food, developmental status and many other factors, all can affect gene expression. This is regulated by several mechanisms (like methylation of DNA), analogous to post-translational modification of proteins. At present, our understanding of this phenomenon is rudimentary at best. " " http://lnkd.in/3rp6Bz View in LinkedIn

INHERITING LEARNED EXPERIENCES: Scientists discover how epigenetic information could be inherited: Mechanism of epigenetic reprogramming revealed: " " http://lnkd.in/VyfjUf View in LinkedIn

LAMARCK would be vindicated, as trait inheritance paradigm breaks. "The discovery that acquired characteristics can be inherited too is big news. For most of the 20th century, biology held that genes were the sole mechanism of inheritance, and that changes in genes occurred only through the random walk of mutation and the relentless sieve of natural selection."" " http://lnkd.in/gv69hw View in LinkedIn

EPIGENETICS will change the utility of gene sequencing as a prognostic diagnosis if environmental triggers can turn on and off genes. It wi also open up new DNA targeted druggable sites for future therapy. " " http://lnkd.in/_4Kthg View in LinkedIn

NEW DRUGGABLE HORIZONS are opening up? If the currently addressed percent of the druggable human genome was estimated at some 2-5%, it is probable that this percentage will drop dramatically as we learn what functions the non-coding sequences ("Junk DNA") serve in the human genome (since they occupy the vast majority of the human genome). They will now be numerous novel druggable targets (with new Mechanisms of Action) as they get revealed. This is great news for pharmaceutical ventures. View in LinkedIn

POST-GENOMIC ERA of epigenetics will mean that purely sequence data for some disease genes may not be enough. Assessment of whether a gene is active or not (by methylation analysis etc) is an important emerging consideration. New sample prep methods may be needed to assess both sequences and epigenetic changes. See this great slide show. " " http://lnkd.in/rUwHBY View in LinkedIn

EPIGENETICS and cancer diagnosis: a good Q&A. " " http://lnkd.in/VVmCxT View in LinkedIn

DATA WAREHOUSING is needed for giant biological data mining projects in epigenetics: "Recently-launched large-scale initiatives include, among others, IHEC (International Human Epigenome Consortium), which plans to map up to 1,000 reference epigenomes within a decade, and the Human Epigenome Project (HEP), which aims to identify, catalog and interpret genome-wide DNA methylation patterns of all human genes in all major tissues."" " http://lnkd.in/csWFKP View in LinkedIn

LARGE CANCER STUDIES: "Epigenetic abnormalities have been found to be causative factors of cancer, genetic disorders and pediatric syndromes, as well as ...autoimmune diseases and aging.Two of the large-scale project initiatives for cancer research include ICGC and TCGA (The Cancer Genome Atlas). TCGA...intends to chart the genomic changes involved in more than 20 types of cancers."" " http://lnkd.in/csWFKP. View in LinkedIn

BIG DATA IN EPIGENOMICS: "Generation of enormous amounts of data has driven the need for more advanced storage solutions and shared access through a range of public repositories. The number of such biomedical resources is increasing constantly and mining these large and diverse data sets continues to present real challenges."" " http://lnkd.in/csWFKP. View in LinkedIn