Year: 2022

MENDELIAN EXCEPTIONS. "There are many situation where the progeny phenotypes do not match the Mendelian principles. The non-Mendelian inheritance pattern plays a role in several processes of diseases." https://lnkd.in/dNPTzz9 View in LinkedIn

NON-MENDELIAN INHERITANCE. "Researchers have identified more than 5,000 genetically inherited human diseases and abnormalities. As we learn more about the inheritance patterns for these traits, it is becoming clear that at least some of the twelve exceptions to the simple Mendelian rules of inheritance described here are, in fact, relatively common. It would not be surprising if other "exceptions" were discovered in the future." https://lnkd.in/dU9C5cY View in LinkedIn

"A FUNDAMENTAL TENET of classical mendelian genetics is that allelic information is stably inherited from one generation to the next, resulting in predictable segregation patterns of differing alleles." https://lnkd.in/dQPBBj4 View in LinkedIn

MENDELIAN BOMBSHELL. "Genome-wide non-Mendelian inheritance of extra-genomic information in Arabidopsis. Here we show that Arabidopsis plants homozygous for recessive mutant alleles of the organ fusion gene HOTHEAD 5 (HTH) can inherit allele-specific DNA sequence information that was not present in the chromosomal genome of their parents but was present in previous generations." http://www.nature.com/nature/journal/v434/n7032/abs/nature03380.html View in LinkedIn

FLAWS IN MENDEL'S LAWS. "Challenging a scientific law of inheritance that has stood for 150 years, scientists say plants sometimes select better bits of DNA in order to develop normally even when their predecessors carried genetic flaws...researchers found that a watercress plant sometimes corrects the genetic code it inherited from its flawed parents and grows normally like its grandparents and other ancestors." https://lnkd.in/dntMsUY View in LinkedIn

HIDDEN GENETIC TEMPLATES. "These mutant parent plants apparently have hidden templates containing genetic information from the preceding generation that can be transferred to their offspring, even though the traits aren't evident in the parents." (Robert Pruitt). https://lnkd.in/dtXtGxH View in LinkedIn

"THE FIRST CLUE that the classic inheritance rules didn't always apply was the discovery of normal flowers on some offspring of mutant plants. In the deformed parents, the flowers were fused into tight balls. But in the grandparents and 10 percent of the grandchildren, the buds become 1-millimeter-long, bright white flowers that fully opened and radiated out from the center of a cluster." https://lnkd.in/dtXtGxH View in LinkedIn

PARADIGM BUSTER. "If you take this mutant Arabidopsis, which has two copies of the altered gene, let it seed and then plant the seeds, 90 percent of the offspring will look like the parent, but 10 percent will look like the normal grandparents. Our genetic training tells us that's just not possible. This challenges everything we believe." https://lnkd.in/dtXtGxH View in LinkedIn

IMPORTANT FINDING. "A non-Mendelian system of inheritance has "enormous implications," says Lolle, with the potential to unseat nearly two centuries of assumptions in genetic research. Suddenly during their conversation, the reporter blurted out "someone just broke the embargo - wow, this is going to be bigger than Dolly! The paper was a really Big Bang." https://lnkd.in/dv6b49K View in LinkedIn

POSSIBLE EXPLANATION. "In a communication to Nature, Ray proposed that DNA heteroduplexes had conserved the wild-type alleles; fragments of chromosomes carried on the two independent parental DNA chains were used in a form of mismatch repair to restore the mutants to wild-type, and could account for some of the reversion." http://www.the-scientist.com/?articles.view/articleNo/26000/title/Mendel-upended-/ View in LinkedIn