Year: 2022

NON-CODING DNA. "Lack of conservation does not impute lack of function, as variation underlies natural selection." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

SHAPE SPECIFYING FUNCTION. "Given that the molecular function of ncRNA may at least be partially conveyed through secondary or tertiary structures, mining evolutionary data for evidence of such features promises to increase the resolution of functional genomic annotations." (ncRNA = non coding RNA). http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

CONFORMATION CONFERS FUNCTION in prions. "Changes in protein conformation drive most biological processes, but none have seized the imagination of scientists and the public alike as have the self-replicating conformations of prions." https://lnkd.in/g53v37B View in LinkedIn

MUTATIONS SHELTERED. "When RNAs function through their 2D or 3D structural conformations, mutations are often tolerated provided that they maintain complementary base pairing—an occurrence termed covariation, which is a bona fide indication of evolutionary selection on RNA structure." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

FASTER EVOLUTION. "The mutational flexibility of ncRNA allows for faster evolutionary substitution rates than proteins, entailing discrete patterns of mutation that are sufficient to predict function." (ncRNA = Noncoding RNA). http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

WIDESPREAD FUNCTIONALITY. "The findings presented herein provide novel evidence for widespread functionality acting through RNA secondary structure, under the premise that negative evolutionary selection is a bona fide indicator of molecular function, in conjunction with the fact that the majority of the human genome is transcribed." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

OLD PARADIGM REFUTED. "Our findings provide an additional layer of support for previous reports advancing that >20% of the human genome is subjected to evolutionary selection, while suggesting that additional evidence for function can be uncovered through careful investigation of analytically involute higher-order RNA structures." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

MILLIONS OF CANDIDATES. "Although this work identifies millions of putative functional RNA structures, their exact functional nature remains largely uncharted. One way to achieve this is by clustering them into families based on their structural topologies, thus deriving function via homology—an approach that has been applied to smaller sets of RNA structures." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

FUNCTIONAL DARK MATTER. "Our findings reappraise the amount of functional sequence in mammalian genomes through comparative genomics by providing further evidence for widespread negative selection at the transcriptomic level." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

REGULATORY FUNCTIONS. "Bearing in mind that the vast majority of the mammalian genome is dynamically transcribed in different cells and developmental stages, these observations are consistent with the hypothesis that non coding RNAs are prevalent molecular conveyors of regulatory plasticity in mammals." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn