Year: 2022

UNIVERSAL. “The AND gate is demonstrated to be modular by applying new regulated promoters to the inputs, and connecting the output to a NOT gate module to produce a combinatorial NAND gate.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

KIT BASED. “The circuits were assembled using a parts-based engineering approach of quantitative characterization, modelling, followed by construction and testing.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

QED. “The results show that new genetic logic devices can be engineered predictably from novel native orthogonal biological control elements using quantitatively in-context characterized parts.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

CASCADE AND INTEGRATE. “As Boolean logic gates are widely used in electronic circuits to build digital devices, logic operations are encoded in gene regulatory networks that cells use to cascade and integrate multiple environmental and cellular signals and to respond accordingly.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

PROGRAMMABLE CELLS. “Thus, by designing customized genetic logic circuits to link various cellular sensors and actuators, we can program living cells to generate precise desired behaviours in response to specific extra or intra-cellular signalling inputs.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

COMPLEX INPUTS. “In particular, multiple-input genetic logic gates are necessary for cells to recognize complex conditions that are normally specified by a combination of several signals (for example, pH, temperature, small molecules or metal ions), and thus can greatly improve the sensing specificity and increase the accuracy of biological control.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

TOXIN SENSING. “For example, various environmental pollutant-like arsenic, xylene and Pseudomonas aeruginosa-responsive sensors can be wired to a multiple-input AND gate, allowing cells to report and neutralize a combinatorial toxic circumstance.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

CLINICAL USE. “The AND gate inputs can also be connected to certain disease-related signal responsive promoters and the output to a therapeutic gene to achieve highly specific in vivo targeting and curing of diseased cells.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

ADVANCED USES. “Furthermore, multiple logic gates can be combined to build larger information-processing circuits with advanced cellular functions, such as a projected image edge detector and even a cellular event counter.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

ANTIMATTER IN COSMIC RAYS.(1a) “Stationary outflow of matter from the surface of antistars. If the diapason of propagation of antimatter from the globular cluster crosses the galactic disk, then the stellar wind will enter the disk, and then into the solar system.” https://lnkd.in/gDYri97U View in LinkedIn