linkedin post 2017-12-24 06:48:10

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SO ENDS this first of two weekends’ glimpse into dimensional scale in our universe and where living things fit into it. What is truly breathtaking is how recently we have had any idea how big the universe is or that we are not the crown of creation on the most important planet in that huge space. It equally parallels how profoundly ignorant we are about life on Planet Earth. We are just jumped-up cave men in fancy clothes with a few fancy toys, nothing more. View in LinkedIn
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linkedin post 2017-12-28 04:22:54

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OXIDATIVE STRESS HYPOTHESIS. "This scenario presupposes that DNA maintenance is inefficient in the absence of meiosis; however, prokaryotes (including archaea) have efficient repair mechanisms that involve recombination but not meiosis. In addition, this scenario does not fit well with the observation that a large number of DSBs are actively generated at the onset of meiosis." (DSB = double strand breaks). http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn
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linkedin post 2017-12-26 05:49:37

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THE TOPIC BREADTH. "We discuss the origin of meiosis (origin of ploidy reduction and recombination, two-step meiosis), its secondary modifications (in polyploids or asexuals, inverted meiosis), its importance in punctuating life cycles (meiotic arrests, epigenetic resetting, meiotic asymmetry, meiotic fairness) and features associated with recombination (disjunction constraints, heterochiasmy, crossover interference and hotspots)." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn
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linkedin post 2017-12-28 04:21:28

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NUMBER 2: OXIDATIVE STRESS. "Another hypothesis is that pairing and recombination initially arose as a way to repair mutational damage caused by increased oxidative stress due to rising atmospheric oxygen or endosymbiosis." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn
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linkedin post 2017-12-26 05:47:41

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DIPLOID TO HAPLOID. "Meiosis is a type of cell division that reduces the number of chromosomes in the parent cell by half and produces four gamete cells. This process is required to produce egg and sperm cells for sexual reproduction. During reproduction, when the sperm and egg unite to form a single cell, the number of chromosomes is restored in the offspring." https://lnkd.in/eTsFK2C View in LinkedIn
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linkedin post 2017-12-28 04:18:04

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NUMBER 1: RETROTRANSPOSONS. "One hypothesis is that meiotic pairing and extensive homologous recombination in meiosis evolved to avoid the burden and consequences of non-allelic ectopic recombination in the large genomes of early eukaryotes, which have repetitive sequences. Such sequences might have been related to the spread of retrotransposons in early eukaryotes, of which many types are very ancient in eukaryotes but absent in bacteria and archaea." https://lnkd.in/e2tp_G5 View in LinkedIn
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linkedin post 2017-12-28 04:13:45

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UBIQUITOUS HOMOLOGOUS RECOMBINATION. "Most evidence suggests that homologous recombination evolved long before meiosis, as it occurs in all domains of life and involves proteins that share strong homology, but the origins and selective advantage of synapsis, gene conversion and recombination remain poorly understood." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn
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