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PATIENT DAYA CLOUD. “Last but not least, genomics will need to leverage systems biology by building predictive models from personal genome data to produce actionable results for patient care that delivers on the promise of precision medicine.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

BEYOND DATA ALONE. “Instead, we need to leverage the ideas and techniques of systems biology to understand the behavior of the system and its multitude of parts. Similarly, the challenges that genomics is now tackling by integratively analyzing ever higher-dimensional, multi-species systems will likely require the development of more sophisticated hierarchical models by the systems biology community to enable meaningful joint comparative analyses.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

EXPERIMENTAL TEST. "There are at least two ways in which the mortality or immortality of animal cells can be determined. First, cells can be serially cultured in laboratory glassware and second, cells having specific markers allowing them to be distinguished from host animal cells, can be serially transplanted in isogeneic laboratory animals. The transplanted tissue is then regrafted to a younger host when the donor host becomes old." https://lnkd.in/dQ_65Wv View in LinkedIn

LESTAT, the Anne Rice vampire said: "when you're immortal that can be a really long and ignominious death." The ennui of an eternal struggle to keep up endless enthusiasm. https://lnkd.in/dsxg8m3 View in LinkedIn

CONTRARIAN'S WISH. "The fact that immortality, in its stricter definitions has never been demonstrated, even in unicellular forms, provides strong support for the likelihood, if not the hope, that it will not be found to occur in higher forms." https://lnkd.in/esfPTAR View in LinkedIn

THE KEEN POINT. "Biologically immortal organisms do die, but they don't seem to age." http://www.bbc.com/earth/story/20150622-can-anything-live-forever View in LinkedIn

"BIOLOGICAL IMMORTALITY refers to a stable or decreasing rate of mortality from senescence, thus decoupling it from chronological age. Various unicellular and multicellular species, including some vertebrates, achieve this state either throughout their existence or after living long enough. A biologically immortal living being can still die from means other than senescence, such as through injury or disease. The term is also used by biologists to describe cells that are not subject to the Hayflick limit." https://en.m.wikipedia.org/wiki/Biological_immortality View in LinkedIn

TIME IN PHYSICS. “Physics is the only science that explicitly studies time, but even physicists agree that time is one of the most difficult properties of our universe to understand.” https://lnkd.in/dn7qBvV View in LinkedIn

MUDDY TERMS. "Normal cultured cell populations are mortal but cells that are immortal are abnormal and most have properties of cancer cells. Nevertheless, this distinction becomes blurred because the terms ‘mortality’ and ‘immortality’ are subject to enormous variations in understanding." (Leonard Hayflick). https://lnkd.in/esfPTAR View in LinkedIn

FRAGMENT FROM NATURE continues this final weekend from last weekend on the subject of biological time, which has been largely ignored in the literature. Time, it seems, scales with both size and complexity; and as complexity increases in biological systems, time plays a critical role in the coordination and intermeshing of numerous processes, in coordination with space, and in this, reflects that biology is centered, like physics, on both time and space, whether we appreciate it or not. View in LinkedIn