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BIOLOGICAL FUNCTIONS OF MEIOSIS #3. "Third, that it is essential, at least in animals, for the reprogramming of gametes which give rise to the fertilized egg." https://lnkd.in/dx9WaSq View in LinkedIn

BIOLOGICAL FUNCTIONS OF MEIOSIS #2. "Second, that recombination at meiosis plays an important role in the repair of genetic defects in germ line cells." https://lnkd.in/dx9WaSq View in LinkedIn

BIOLOGICAL FUNCTIONS OF MEIOSIS #1. "Four possible biological functions of meiosis are considered. First, the conventional view that it generates by recombination and sexual reproduction the genetic diversity on which natural selection can act." https://lnkd.in/dx9WaSq View in LinkedIn

REPEAT CIRCLE INVASION. "I propose that linear chromosomes arose as the consequence of the invasion of a circular genome with repeat sequences." https://lnkd.in/d8Qr_bk View in LinkedIn

WHY MEIOSIS? “We regard meiosis as accomplishing four functions: (1) reducing ploidy (parasexuality also accomplishes this, albeit less efficiently); (2) purging deleterious alleles and unmasking advantageous recessives when meiotic products are haploid (parasexuality also does this); (3) reducing ploidy while also generating complete chromosome sets rather than incomplete or chaotic sets (the elegance of meiosis I); and (4) generating recombinant offspring via independent assortment and crossing over in heterozygotes.” http://cshperspectives.cshlp.org/content/6/3/a016154.full View in LinkedIn

GENOMIC STREAMLINING. "Genomic researchers have proposed that natural selection may favor small genomes—weeding out superfluous material—through a process called “genomic streamlining.” Streamlining makes inherent sense because a small genome should aid metabolic efficiency, because genome size is correlated with cell size." https://lnkd.in/d3Ys7Am View in LinkedIn

GENOME DOWNSIZING. "Evolutionary chromosome change involves significant variation in DNA amount in diploids and genome downsizing in polyploids." https://lnkd.in/dmkwGfy View in LinkedIn

SIMPLICITY NOT SELECTED. "In part, the answer must be that most processes in eukaryotes generally evolve toward complexity, presumably because complexity provides more regulatory opportunities and perhaps also because there is no selective pressure to enforce simplicity." Not always true. https://lnkd.in/d8Qr_bk View in LinkedIn

SPLICEOSOME COMPLEXITY. "The same question could be asked about intron splicing which evolved from simple self-splicing based on RNA catalysis to elaborate spliceosomal complexes with a myriad of RNA and protein components." https://lnkd.in/d8Qr_bk View in LinkedIn

TELOMERE COMPLEXITY. "The scenario sketched above raised the question why telomeres became so elaborate. Why not stick with the simple t-loop mode? Why have telomerase and a host of telomeric proteins?" https://lnkd.in/d8Qr_bk View in LinkedIn