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APPROXIMATE FIDELITY. "A closer approximation to fidelity is that each zygote in the lineage contains the same genetic information as does its precursors following fertilization. This is dubious because of the occurrence of mutations, one of the few universal properties of life." (L. Haflick, contrarian). https://lnkd.in/esfPTAR View in LinkedIn

ORIGIN OF GERM LINE. "The molecular events that trigger the separation of the germ line from the soma in the early embryo are still largely undefined." http://www.reproduction-online.org/content/revreprod/5/2/93.full.pdf View in LinkedIn

TOTIPOTENT. "The early germ line may be referred to as totipotent." http://www.reproduction-online.org/content/revreprod/5/2/93.full.pdf View in LinkedIn

POPULATION IMMORTALITY. "One problem that arises in discussing the nature of the germ line is nomenclature and the use of the terms ‘immortal’ and ‘totipotent’. Although the germ line is frequently referred to as ‘immortal’, this is only valid at the level of the entire population and, more specifically, only the genome residing within the cells that compose the germ line may be viewed as immortal." http://www.reproduction-online.org/content/revreprod/5/2/93.full.pdf View in LinkedIn

UNUSUAL REPROGRAMMING. "Germline epigenetic reprogramming in addition to requiring epigenetic modification to compose the germline, the primordial germ cells uniquely undergo striking wave of epigenetic reprogramming that most other lineage do not undergo." http://www.sciencedirect.com/science/article/pii/S2305050015000524 View in LinkedIn

"EPIGENETIC REPROGRAMMING can be explained as any mitotic or meiotic changing which does not result any alteration in DNA sequence but will have important effect on the normal embryonic development." (Explained or defined?). http://www.sciencedirect.com/science/article/pii/S2305050015000524 View in LinkedIn

ESSENTIAL. "In recent years, it has become consummately clear that changing of epigenetic modification is essential during both early and late oogenesis and spermatogenesis." https://lnkd.in/gCPVDZd View in LinkedIn

Routine DNA tests will put NHS at the 'forefront of medicine' https://www.theguardian.com/science/2018/jul/03/nhs-routine-dna-tests-precision-cancer-tumour-screening?CMP=Share_iOSApp_Other View in LinkedIn

TWO FATES. "Epigenetic information is frequently erased near the start of each new generation. In some cases, however, epigenetic information can be transmitted from parent to progeny (multigenerational epigenetic inheritance)." http://www.nature.com/nature/journal/v489/n7416/abs/nature11352.html View in LinkedIn

REPROGRAMMING. "It has long been suspected that epigenetic modifications could play a role in limiting the developmental potential of a tissue during the complex pattern of tissue differentiation. This has led to the idea that a fundamental aspect of the difference between the ‘‘mortal’’ soma and the ‘‘immortal’’ germline may be the ability to reprogram the genome of the germ cells epigenetically in order to maintain totipotency." View in LinkedIn