Category: Uncategorized

MUDDY POND. "Normal cultured cell populations are mortal but cells that are immortal are abnormal and most have properties of cancer cells. Nevertheless, this distinction becomes blurred because the terms ‘mortality’ and ‘immortality’ are subject to enormous variations in understanding." (Leonard Hayflick). https://lnkd.in/dPSTAYE View in LinkedIn

WIDESPREAD HYBRIDIZATION. "Hybridisation was traditionally considered rare on coral reefs. However, a rapid increase in hybrid studies over the last 20 years has revealed that hybridisation on coral reefs is common and widespread." https://lnkd.in/dfcW_XQ View in LinkedIn

DISRUPTIVE SCIENCE. "In the 1960’s, Leonard Hayflick and Paul Moorhead overturned what was then a reigning paradigm in cell biology--that under optimal growth conditions, cells possessed an unlimited capacity for replication. Their elegant series of experiments convincingly showed that, on the contrary, human cells displayed a strictly limited division potential." https://lnkd.in/dppQZ73 View in LinkedIn

CANCER IMMORTALITY. "But, is it really true that cell immortality exists in vitro? Is HeLa, for example, immortal? In fact, it has never been proven." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

THERE ARE NO IMMORTAL NORMAL CELLS. "As a result of our demonstration that normal cells are mortal, the focus of attention in the field of aging began to be directed to the cell itself, and the dogma of fifty years duration began to die a slow death." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

"THE FINITUDE of normal cell replication has been substantially demonstrated to occur both in vivo and in vitro." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

FUTILE SEARCH. "The failure of grafted normal cells to replicate indefinitely in vivo means that, given the "perfect" conditions of nutrition and environment that an isologous animal represents, transplanted normal cells are still incapable of immortality. This leads to the further conclusion that a search for perfect in vitro conditions in which normal cells might reveal immortality is futile." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

THE MORTALITY REALITY. "As Weismann opined, renewal cell populations do not occur in most tissues, and when the do, cell proliferation is not indefinite. In vitro experiments yield similar results. Serially cultured normal cells are mortal and reveal age changes before they die." (Normal cells). http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

THE IMMORTALITY CONDITION. "If all cell types were continually renewed without loss of function or capacity for self-renewal, organs composed of such cells would be expected to function normally indefinitely. Their host would live forever." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

CRYOGENIC PRESERVATION. "The cells have an extraordinary memory and "remember" at what doubling level the were preserved even after 35 years of continuous storage in liquid nitrogen. WI-38 has been cryogenically preserved longer than any other normal human or animal cell population." (There is a very interesting story behind WI-38 cells if you care to look it up). http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn