linkedin post 2018-08-22 06:05:07

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APPLICATIONS. “The observation that telomerase is qualitatively expressed only in cancer cells or is expressed quantitatively less per cell in differentiating cells has sparked interest in finding inhibitors of telomerase as a novel approach to cancer therapy.” http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn
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linkedin post 2018-08-22 06:02:38

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SECOND EXCEPTION. “How do the cells composing immortal populations avoid telomere shortening that, if it occurs, would lead to their demise? They found that telomeres are synthesized de novo by telomerase, a ribonucleoprotein enzyme that extends the 3´ end of telomeres and thus elongates them. This ribonucleoprotein complex contains a reverse transcriptase and RNA template for the synthesis of the repeated sequence. Telomerase was later found to occur in extracts of immortal human cells.” http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn
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linkedin post 2018-08-24 03:53:10

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ANCIENT BACTERIA AND LONGEVITY. “The gerontogenes are classified as lifespan regulators, mediators, effectors, housekeeping genes, genes involved in mitochondrial function, and genes regulating cellular senescence and apoptosis. In this review we demonstrate that the majority of the genes as well as genetic and epigenetic mechanisms that are involved in regulation of longevity are highly interconnected and related to stress response.” The mitochondrion originated from an engulfed bacteria. http://www.tandfonline.com/doi/abs/10.4161/cc.28433 View in LinkedIn
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linkedin post 2018-08-22 06:00:56

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THE AGING CLOCK. “Telomeric shortening, which occurs in several classes of dividing normal somatic cells, may be the replicometer that determines the number of times that a normal cell is able to divide. Once a critical or threshold number of telomeric TTAGGG repeats is reached, cells will then be unable to divide.” http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn
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linkedin post 2018-08-24 03:51:43

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GERONTOGENES. “The study of human and animal genetics is gradually identifying new genes that increase lifespan when overexpressed or mutated: gerontogenes. Furthermore, genetic and epigenetic mechanisms are being identified that have a positive effect on longevity.” https://lnkd.in/dU6CpHu View in LinkedIn
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linkedin post 2018-08-22 05:57:08

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CREATIVE SOLUTION. “Eukaryotic cells have evolved a novel solution to the end replication problem in which the specialized chromosome end structures, or telomeres, contain repetitive sequences, some of which are lost at each round of replication. The loss of these sequences, which lack the information contained in downstream genes, acts as a buffer protecting those genes from loss during each round of DNA replication.” http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn
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