Category: Uncategorized

CANDIDATE LONGEVITY GENES. “The partners of known LAGs in the worm and human longevity networks may participate in the intricate pathways and complexes that regulate lifespan, and are therefore candidate longevity genes. Our primary analysis, 156 of these inactivations resulted in extended (101) or decreased (55) lifespan. We confirmed a subset (30 genes) of these phenotypes in rigorous longitudinal analyses.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

STRESS GENES CAN EXTEND LIFESPAN. “This finding appears to illustrate the antagonistic pleiotropy theory of aging, which suggests that the post-reproductive decrescendo of the force of natural selection permits the evolution of genes that are essential early in life but detrimental late in life.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

0 View in LinkedIn

STRESS AND LONGEVITY GENES. “Overexpression of most of these genes extends lifespan and, where tested, increases stress tolerance” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

STRESS GENES. “A study of over 50 long-lived C. elegans mutants reveals that each is resistant to one or more stressors, such as oxidative damage, heat stress or irradiation. Many genes required for the successful extension of lifespan in one or more long-lived mutants also contribute to the longevity of wild-type animals, but are distinguished by a proportionally greater change in the mutant background.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

LIFE SPAN AND STRESS. “Known longevity genes are enriched for roles in stress tolerance and development. Many mutations that modulate longevity were identified by virtue of their contribution to stress response pathways or by homology to genes of this kind.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

LIFE SPAN REGULATORS. “Our results suggest that the worm and human longevity networks are functionally relevant and possess a high predictive power for identifying new longevity regulators.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

GENES AND LIFE SPAN. “Curran and Ruvkun explored this overlooked gene set by inactivating essential genes postdevelopmentally, revealing 64 genes required for development that extend lifespan when inactivated during adulthood. Nevertheless, many important longevity genes likely remain unidentified.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

DARWINIAN LIFE SPAN. “We interpret life span as an inherent property of self-organizing systems that, accordingly, maintain species-specific limits for the entire complex of fitness traits. We conclude that Darwinian approaches provide unique opportunities to discover the biological bases of longevity as well as devise individual specific medical or other interventions toward improving health span.” http://link.springer.com/chapter/10.1007/978-1-4939-2404-2_1 View in LinkedIn

COMPOSITE TRAIT. “As an important life-history trait, longevity shows ontogenetic relationships with other complex traits, and hence may be viewed as a composite trait. Factors that influence the origin and maintenance of diversity of life are ultimately governed by Darwinian processes.” http://link.springer.com/chapter/10.1007/978-1-4939-2404-2_1 View in LinkedIn