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SIROLIMUS, an anti-organ rejection drug, called "Rapamycin is shown to increase longevity by inhibiting the target of rapamycin kinase (TOR). Study systems including yeast, nematodes, flies, and mammals, have shown that reduction of TOR signaling will result in an increased life span." http://en.m.wikipedia.org/wiki/Life_extension View in LinkedIn

REVERSING STEM CELL SENESCENCE."Researchers were able to turn back the molecular clock by infusing the blood stem cells of old mice with a longevity gene and rejuvenating the aged stem cells’ regenerative potential. “We already know that sirtuins regulate aging, but our study is really the first one demonstrating that sirtuins can reverse aging-associated degeneration. This opens the door to potential treatments for age-related degenerative diseases.” https://lnkd.in/dEjczux View in LinkedIn

MAKING MICE HEARTS YOUNGER. “In this study, we were able to show that a protein that circulates in the blood is related to this aging process, and if we gave older mice this protein, we could reverse the heart aging in a very short period of time,” Lee said. “We are very excited about it because it opens a new window on the most common form of heart failure.” https://lnkd.in/dSqtGre View in LinkedIn

STEM CELLS FOR TISSUE DAMAGE. “Taking their cue from salamander regeneration, a team led by the University of New South Wales says that a stem cell therapy capable of regenerating any human tissue damaged by injury, disease, or aging could be available within a few years, thanks to an innovative new technique.” https://lnkd.in/djdqzys View in LinkedIn

CANDIDATE GENES EMERGE. “In the largest linkage scan thus far performed for human familial longevity, we confirm that the APOE locus is a longevity gene and that additional longevity loci may be identified at 14q11.2, 17q12-q22, and 19p13.3-p13.11. As the latter linkage results are not explained by common variants, we suggest that rare variants play an important role in human familial longevity.” (APOE is a class of fat metabolizing pathway proteins linked to Alzheimer’s). http://onlinelibrary.wiley.com/doi/10.1111/acel.12039/full View in LinkedIn

LARGE AGING LINKAGE STUDY. “Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that have been enrolled in 15 study centers of 11 European countries as part of the Genetics of Healthy Aging (GEHA) project.” https://lnkd.in/dT7y7Ze View in LinkedIn

MANY VARIABLES. “The identification of longevity-related genes does not explain the mechanisms of healthy aging and longevity rather pose questions on epigenetic contribution, gene regulation and the interactions with essential genomes, i.e. mitochondrial DNA and microbiota. To fully disentangle what appears to be an endless quest, all the components of the complexity of human longevity genetics are taken into account.” http://www.ingentaconnect.com/content/ben/cvp/2014/00000012/00000005/art00007 View in LinkedIn

METABOLISM AND LONGEVITY. “We found that processes such as lipid metabolism and cholesterol catabolism show such patterns of selection and suggest a link between the evolution of lipid metabolism, cholesterol catabolism, and the evolution of longevity. Lastly, we found evidence that the proteasome–ubiquitin system is under selection specific to lineages where longevity increased and suggest that its selection had a role in the evolution of longevity.” http://link.springer.com/article/10.1007/s11357-011-9361-y View in LinkedIn

ANTI-AGING RESEARCH is a relatively new scientific discipline that has been confounded by the snake-oil brews and claims of the cosmetics industry. Stepping back from this veritable noise, the fact remains that many cellular systems employ strategies that confer remarkable longevity. As these strategies are better understood, and the genes responsible cloned, the opportunities in the future for aging plasticity in man look promising. View in LinkedIn

CROSS-TAXA ANALYSIS. “Thanks to recent large-scale genome sequencing efforts, the genomes of multiple species have been sequenced and can be used for cross-species comparisons to study species divergence in longevity. By analyzing proteins under accelerated evolution in several mammalian lineages where maximum lifespan increased, we identified genes and processes that are candidate targets of selection when longevity evolves.” http://link.springer.com/article/10.1007/s11357-011-9361-y View in LinkedIn