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PROKARYOTIC DEATH GENES. "The caspase gene super-family is involved in cell death in both prokaryotes and eukaryotes, suggesting that it is functionally conserved and arose early in prokaryote evolution." View in LinkedIn

CONSERVED AND ADAPTED. "The ancient and deeply conserved genetic and molecular pathways that cause cell death indicate that death-promoting mechanisms show less variability than would be expected for unavoidable or maladaptive death.” View in LinkedIn

INTERNAL REAPER. "There is substantial evidence that cell death is often internally controlled and regulated in unicellular organisms." View in LinkedIn

PROGRAMMED CELL DEATH "seems paradoxical, however, in cases where the single cell is the entire organism. In some species ambiguity arises as to whether cells are organisms or parts of organisms." View in LinkedIn

REF FOR TODAY’S POST. Are Internal, Death-Promoting Mechanisms Ever Adaptive?" "John W Pepper, Deborah E Shelton, Armin Rashidi and Pierre M Durand" "Journal of Phylogenetics & Evolutionary Biology View in LinkedIn

REF FOR TODAY’S POST. Are Internal, Death-Promoting Mechanisms Ever Adaptive?" "John W Pepper, Deborah E Shelton, Armin Rashidi and Pierre M Durand" "Journal of Phylogenetics & Evolutionary Biology View in LinkedIn

NOVEL FINDING. "Among this subset with eukaryotic sequence homology, the protein domains are almost exclusively found in the phage EAM. An EAM has never before been reported in bacteriophage genomes, to our knowledge, possibly because phages of obligate intracellular bacteria occupy a unique eukaryotic-enclosed niche and are relatively understudied." (EAM = eukaryotic association module). https://lnkd.in/dYh3-r4 View in LinkedIn

SPARING LIMITED RESOURCES. "As one well-studied example, clonal growth of yeast colonies creates opportunities for strong kin selection and evolution of group-beneficial altruistic traits. PCD could serve at least two altruistic purposes in this context. By dying, a cell may spare nutrient resources for its neighboring kin group." (PCD = programmed cellular death). http://www.esciencecentral.org/journals/are-internal-death-promoting-mechanisms-ever-adaptive-2329-9002.1000113.pdf View in LinkedIn

EAM GENES IN PHAGES. "Notably, over half of these domain types share greater amino-acid homology to eukaryotic invertebrates than to bacteria in GenBank." (EAM = eukaryotic association module). https://lnkd.in/dYh3-r4 View in LinkedIn

UNICELLULAR FITNESS SELECTION. "These is considerable experimental evidence for fitness advantages from POD to clonal kin groups of cells of species usually considered to be ‘unicellular’. These fitness advantages may represent a significant source of selection pressure." (POD = programmed organismal death). http://www.esciencecentral.org/journals/are-internal-death-promoting-mechanisms-ever-adaptive-2329-9002.1000113.pdf View in LinkedIn